Disentangling molecular alterations from water-content changes in the aging human brain using quantitative MRI

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Diffusion changes in the aging human brain.

BACKGROUND AND PURPOSE Quantifying changes in the human brain that occur as part of normal aging may help in the diagnosis of diseases that affect the elderly and that cause structural changes in the brain. We sought to assess diffusion changes that are inherently related to brain structure during aging. METHODS MR scans were obtained from 11 healthy volunteers and 27 patients (ages 26 to 86 ...

متن کامل

Water-Specific Quantitative MRI Relaxometry of the Brain using Spatial-Spectral Water Excitation: Preliminary Experience

Methods: The mixed turbo spin echo pulse (mixed-TSE) sequence was implemented with second order binomial water-selective spatial-spectral excitation pulses (1), hereafter SSE-mixed-TSE (Figure 1). Mixed-TSE is a four time point pulse sequence that incorporates the principles of differential T1and T2-weighting in a single acquisition. By substituting the standard spatially-selective excitation p...

متن کامل

MRI assessment of whole-brain structural changes in aging

PURPOSE One of the central features of brain aging is the accumulation of multiple age-related structural changes, which occur heterogeneously in individuals and can have immediate or potential clinical consequences. Each of these deficits can coexist and interact, producing both independent and additive impacts on brain health. Many of the changes can be visualized using MRI. To collectively a...

متن کامل

Quantitative in vivo measurement of gyrification in the human brain: changes associated with aging.

Clinical observation suggests that the aging process affects gyrification, with the brain appearing more 'atrophic' with increasing age. Empirical studies of tissue type indicate that gray matter volume decreases with age while cerebrospinal fluid increases. Quantitative changes in cortical surface characteristics such as sulcal and gyral shape have not been measured, however, due to difficulti...

متن کامل

P 24: Evaluation of the Voxel Based Morphometry in Quantitative Analysis of Brain MRI Images

Introduction: Voxel based morphometry is a type of statistical parametric mapping that can be used to investigate the effect of diseases such as epilepsy, Alzheimer's disease and Parkinson's disease or other agent such as skills on brain structure (white matter, gray matter and cerebrospinal fluid). The aim of this study is evaluate the effectiveness of this method in detection of differen...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Nature Communications

سال: 2019

ISSN: 2041-1723

DOI: 10.1038/s41467-019-11319-1